1 2 3 Simulating serial - target antibacterial drug synergies using flux balance
نویسندگان
چکیده
Simulating serial-target antibacterial drug synergies using flux balance analysis 4 5 6 7 8 9 10 11 Andrew S. Krueger¶, Christian Munck ¶, Gautam Dantas, 12 George M. Church, James Galagan, Joseph Lehár, Morten O.A. Sommer 13 14 1 Boston University, 44 Cummington St, Boston, MA, USA. 15 2 Technical University of Denmark, Novo Nordisk Foundation Center for Biosustainability, Hørsholm, 16 Denmark. 17 3 Center for Genome Science & Systems Biology, Washington University School of Medicine, St 18 Louis, Missouri, USA. 19 4 Department of Pathology & Immunology, Washington University School of Medicine, St Louis, 20 Missouri, USA. 21 5 Department of Biomedical Engineering, Washington University, St. Louis, Missouri, USA. 22 6 Department of Genetics Harvard Medical School, Boston, Massachusetts, USA. 23 7 Broad Institute, Cambridge Center, Cambridge, Massachusetts, USA. 24 25 ¶ Equal contribution 26 * Corresponding authors JL: [email protected], MOAS: [email protected]) 27
منابع مشابه
Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis
Flux balance analysis (FBA) is an increasingly useful approach for modeling the behavior of metabolic systems. However, standard FBA modeling of genetic knockouts cannot predict drug combination synergies observed between serial metabolic targets, even though such synergies give rise to some of the most widely used antibiotic treatments. Here we extend FBA modeling to simulate responses to chem...
متن کاملSynthesis and characterization of high flux and antibacterial film nanocomposite based on epoxy-zeolite NaA
A high flux thin-film nanocomposite membrane epoxy/ zeolite NaA nanocomposite films prepared by using ultrasonic mixing and spin coating. The synthesized nanocomposites film was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal gravity analysis (TGA), and FTIR spectroscopy. Water softener and water flux characteristics of the epoxy/ zeolite NaA nanocomposite ...
متن کاملErratum for Song et al., Exploring Synergy between Classic Mutagens and Antibiotics To Examine Mechanisms of Synergy and Antibiotic Action.
We used classical mutagens in Gram-negative Escherichia coli to study synergies with different classes of antibiotics, test models of antibiotic mechanisms of action, and examine the basis of synergy. We used 4-nitroquinoline 1-oxide (4NQO), zebularine (ZEB), 5-azacytidine (5AZ), 2-aminopurine (2AP), and 5-bromodeoxyuridine (5BrdU) as mutagens (with bactericidal potency of 4NQO > ZEB > 5AZ > 2A...
متن کاملFlux balance analysis of biological systems: applications and challenges
Systems level modelling and simulations of biological processes are proving to be invaluable in obtaining a quantitative and dynamic perspective of various aspects of cellular function. In particular, constraint-based analyses of metabolic networks have gained considerable popularity for simulating cellular metabolism, of which flux balance analysis (FBA), is most widely used. Unlike mechanisti...
متن کاملSynthesis and Antimicrobial Activity of Some 2-Amino-4-(7- Substituted/Unsubstituted Coumarin-3-yl)-6- (Chlorosubstitutedphenyl) Pyrimidines
Purpose: To prepare some 2-amino-4-(7-substituted/unsubstitutedcoumarin-3-yl)-6-(chlorosubstitute dphenyl) pyrimidines as antimicrobial agents. Methods: Some 2-amino-4-(7-substituted/unsubstitutedcoumarin-3-yl)-6-(chlorosubstitutedphenyl) pyrimidines were prepared by reacting 3-chlorosubstitutedphenyl-1-(7-substituted/unsubstituted coumarin-3-yl)prop-2-ene-1-ones with guanidine carbonate. The c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015